Jacksonville,FL - largest city by area in the lower 48

Jacksonville, FL is the largest city by area in the lower 48 states. Like San Antonio and other cities, Jacksonville became huge by "consolidation," annexing many smaller surrounding towns and suburbs into the official city limits.

The Jacksonville Historical Society describes how in 1967 Jacksonville instantaneously became the "biggest city in the world" by annexation.

http://www.jaxhistory.com/journal11.html

Jacksonville is also ranked #1 in cities to start a business due to low tax rates and real estate costs.